Pentamidine dihydrochloride

Research use only, not for human use.

Pentamidine dihydrochloride is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii).

Pentamidine dihydrochloride is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.(In Vitro):Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment.(In Vivo):Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells.

MP-601205 dihydrochloride

Metabolic Enzyme/Protease

Phosphatase

aryl hydrocarbon receptor;GSK-3;CDK1/CyclinB;CDK5/p25

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50357-45-4

413.3

C19H26Cl2N4O2

>98% (HPLC)

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[Cl-].[Cl-].NC(=[NH2+])c1ccc(OCCCCCOc2ccc(cc2)C(N)=[NH2+])cc1

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(-20℃)

With Ice Pack

≥ 2 years